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Unusual pregnancy follow-up 2-year-old Great Dane with suspected hypoluteoidism


A 2-year-old primiparous female Great Dane was presented for ovulation timing and breeding. Progesterone was monitored by means of progesterone chemiluminescence assays (Immulite 2000) and inseminations were performed 48 and 72 hours post ovulation. An ultrasound examination at day 28 post ovulation revealed the presence of at least 5 viable foetuses. Given the presence of cases of hypoluteodism in the bitch's lineage, weekly blood samples were taken to monitor the progressive decline of the progesterone concentration throughout the pregnancy. Hypoluteodism was suspected as an important decrease of progesterone was observed during the gestation: 18, 11 and 9 ng/mL respectively on day 28, 37 and 41 post ovulation. A drop of more than 30% progesterone in one week and a progesterone value below 10 ng/ml at the beginning of the last third of pregnancy are, in our experience, indications for progesterone supplementation. Supplementation with oral natural progesterone was initiated at day 41 (200 mg/ q8h) and continued until day 54. At that point, the bitch started to show signs of restlessness, anorexia, mucous vaginal discharge and lethargy. A follow-up ultrasound scan revealed multiple foetuses with a normal heart rate (>200 bpm) but a progesterone level of 3.6 ng/mL. Treatment was adapted (300 mg/ q 6h) to avoid the beginning of a premature birth, and continued until day 60 post ovulation. A final ultrasound check 61 days post ovulation revealed no foetal distress and the progesterone dosage was stable at 3.8 ng/mL. An injection of aglepristone (RU 46534) at a dose of 15 mg/kg was given on that day. Nine healthy puppies were delivered by elective caesarean-section 62 days post ovulation, without malformation. Normal milk production was initiated just before partition. Although hereditary influence on hypoluteoidism in the bitch is still under discussion, a family history was reported in this case. Natural progesterone was favoured over synthetic progestins for its less incidence of collateral effect on foetuses (masculinisation of female foetuses) and on the pregnancy (dystocia, pyometra, uterine infections). Unusually, signs of whelping were observed at 54 days post ovulation despite existing complementation. An increase in both doses and frequency of progesterone treatment allowed pregnancy to be maintained to term. In light of the lack of literature on hypoluteodism in the bitch, we showcase an example of follow-up and treatment of a suspected case which led to a successful parturition of healthy puppies without foetal losses.
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hal-03720237 , version 1 (11-07-2022)


  • HAL Id : hal-03720237 , version 1


Alessandra Paganotto, Camille Langlade, S. Buff, Emilie Rosset. Unusual pregnancy follow-up 2-year-old Great Dane with suspected hypoluteoidism. 9th International Symposium on Canine and Feline Reproduction, ICAR 2022 Satellite & 24th EVSSAR Congress, Jun 2022, Milano, Italy. ⟨hal-03720237⟩
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