Diagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation - ACL en SVSAE Accéder directement au contenu
Article Dans Une Revue Breast Cancer Research Année : 2021

Diagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation

1 Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe
2 Institut Curie [Paris]
3 Mines Paris - PSL (École nationale supérieure des mines de Paris)
4 PSL - Université Paris sciences et lettres
5 UFIJ - Federal University of Juiz de Fora
6 IGR - Institut Gustave Roussy
7 AP-HP. Université Paris Saclay
8 Hôpital Arnaud de Villeneuve [CHRU Montpellier]
9 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
10 CCS - Centre Catherine-de-Sienne [Nantes]
11 CRLCC Paul Strauss - Centre Paul Strauss
12 CH Georges Renon Niort - Centre Hospitalier Georges Renon [Niort]
13 IPC - Institut Paoli-Calmettes
14 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
15 CHU Dijon
16 UNICANCER/CRLCC-CGFL - Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon]
17 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
18 CHR Metz-Thionville - Centre hospitalier régional Metz-Thionville
19 Hôpital de Mercy
20 Centre René Gauducheau
21 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
22 Centre Léon Bérard [Lyon]
23 HUS - Les Hôpitaux Universitaires de Strasbourg
24 Institut Bergonié [Bordeaux]
25 IMoST - Imagerie Moléculaire et Stratégies Théranostiques
26 UNICANCER/CJP - Centre Jean Perrin [Clermont-Ferrand]
27 Ramsay Générale de Santé - Hôpital Privé La Louvière
28 Hôpital Dupuytren [CHU Limoges]
29 Institut Sainte Catherine [Avignon]
30 hôpital couple-enfant [CHU Grenoble Alpes]
31 Institut Claudius Regaud
32 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
33 Hôpital Bretonneau
34 Hôpital Morvan [Brest]
35 CHU Tenon [AP-HP]
36 HCL - Hospices Civils de Lyon
37 GHE - Groupement Hospitalier Lyon-Est
38 Clinique de Génétique médicale Guy Fontaine [CHRU LIlle]
39 Hôpital pasteur [Colmar]
40 CHU Nîmes - Hôpital Universitaire Carémeau [Nîmes]
41 CHU de Bordeaux Pellegrin [Bordeaux]
42 Centre Hospitalier Métropole Savoie [Chambéry]
43 Hôpital René Huguenin [Saint-Cloud]
44 CHU Rouen
45 Hôpital Edouard Herriot [CHU - HCL]
46 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
47 U830 - Unité de génétique et biologie des cancers
48 UPD5 - Université Paris Descartes - Paris 5
Florent Soubrier
Anne Fajac
  • Fonction : Auteur
Thierry Frebourg
  • Fonction : Auteur

Résumé

Diagnostic ionizing radiation is a risk factor for breast cancer (BC). BC risk increases with increased dose to the chest and decreases with increased age at exposure, with possible effect modification related to familial or genetic predisposition. While chest X-rays increase the BC risk of BRCA1/2 mutation carriers compared to non-carriers, little is known for women with a hereditary predisposition to BC but who tested negative for a BRCA1 or BRCA2 (BRCA1/2) mutation. Methods We evaluated the effect of chest X-rays from diagnostic medical procedures in a dataset composed of 1552 BC cases identified through French family cancer clinics and 1363 unrelated controls. Participants reported their history of X-ray exposures in a detailed questionnaire and were tested for 113 DNA repair genes. Logistic regression and multinomial logistic regression models were used to assess the association with BC. Results Chest X-ray exposure doubled BC risk. A 3% increased BC risk per additional exposure was observed. Being 20 years old or younger at first exposure or being exposed before first full-term pregnancy did not seem to modify this risk. Birth after 1960 or carrying a rare likely deleterious coding variant in a DNA repair gene other than BRCA1/2 modified the effect of chest X-ray exposure. Conclusion Ever/never chest X-ray exposure increases BC risk 2-fold regardless of age at first exposure and, by up to 5-fold when carrying 3 or more rare variants in a DNA repair gene. Further studies are needed to evaluate other DNA repair genes or variants to identify those which could modify radiation sensitivity. Identification of subpopulations that are more or less susceptible to ionizing radiation is important and potentially clinically relevant.
Fichier principal
Vignette du fichier
s13058-021-01456-1.pdf (843.79 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03345365 , version 1 (17-09-2021)

Licence

Paternité

Identifiants

Citer

Maximiliano Ribeiro Guerra, Juliette Coignard, Séverine Eon-Marchais, Marie-Gabrielle Dondon, Dorothée Le Gal, et al.. Diagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation. Breast Cancer Research, 2021, 23 (1), ⟨10.1186/s13058-021-01456-1⟩. ⟨hal-03345365⟩
315 Consultations
59 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More